Биоинформатика. Порозов Ю.Б. - 48 стр.

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Университет ИТМО | Санкт-Петербург

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15. Посмотрите на ваш документ genia и определите, какие аннотации
были выбраны в нем GATE.
Приложения к лабораторной работе № 7
Приложение 1. GENIA corpus .xml
Приложение 2
Genia corpus неразмеченный
MEDLINE:95369245
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive
oxygen production by 5-lipoxygenase .
Activation of the CD28 surface receptor provides a major costimulatory
signal for T cell activation resulting in enhanced production of interleukin-2 (
IL-2 ) and cell proliferation.
In primary T lymphocytes we show that CD28 ligation leads to the rapid
intracellular formation of reactive oxygen intermediates ( ROIs ) which are
required for CD28 -mediated activation of the NF-kappa B / CD28 -responsive
complex and IL-2 expression.
Delineation of the CD28 signaling cascade was found to involve protein
tyrosine kinase activity , followed by the activation of phospholipase A2 and 5-
lipoxygenase.
Our data suggest that lipoxygenase metabolites activate ROI formation which
then induce IL-2 expression via NF-kappa B activation .
These findings should be useful for therapeutic strategies and the
development of immunosuppressants targeting the CD28 costimulatory
pathway.
MEDLINE:95333264
The peri-kappa B site mediates human immunodeficiency virus type 2
enhancer activation in monocytes but not in T cells .
Human immunodeficiency virus type 2 ( HIV-2 ) , like HIV-1 , causes AIDS
and is associated with AIDS cases primarily in West Africa.
HIV-1 and HIV-2 display significant differences in nucleic acid sequence and
in the natural history of clinical disease.
Consistent with these differences , we have previously demonstrated that the
enhancer/promoter region of HIV-2 functions quite differently from that of
HIV-1.
Whereas activation of the HIV-1 enhancer following T-cell stimulation is
mediated largely through binding of the transcription factor NF-kappa B to two
adjacent kappa B sites in the HIV-1 long terminal repeat, activation of the
HIV-2 enhancer in monocytes and T cells is dependent on four cis-acting
elements : a single kappa B site, two purine-rich binding sites, PuB1 and PuB2,
and a pets site.

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